HRID2262302

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22309453

(3-{[(Methanesulfonyl)amino]methyl}phenyl)boronic acid

C8H12BNO4S

HCID24208789

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

C13H17BN2O2

HCID59592880

未命名化合物

PRODUCTS

生成物

结构：Cc1c(-c2cccc(CNS(C)(=O)=O)c2)sc2c(N3CCOCC3)nc(-c3cnc4[nH]ccc4c3)nc12

HCID59592861

未命名化合物

PROCEDURE

实验过程

2-Chloro-6-iodo-7-methyl-4-morpholinothieno[3,2-d]pyrimidine (50 mg) was coupled to 3-methanesulphonylamino methyl benzeneboronic acid, and then reacted with 7-azaindole-5-boronic acid pinacol ester via General Procedure F. The product was purified by reverse phase HPLC to yield 34.5 mg of 424. MS (Q1) 535.2 (M)+

WORKUP

后处理

customThe product was purified by reverse phase HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cf41e71b66264160990200fa715a20db
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07846929B2
来源说明: uspto-grants-2010_12

反应 SMILES

Cl[C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9](I)=[C:8]([CH3:12])[C:6]=2[N:7]=1.[CH3:19][S:20]([NH:23][CH2:24][C:25]1[CH:26]=[C:27](B(O)O)[CH:28]=[CH:29][CH:30]=1)(=[O:22])=[O:21].[NH:34]1[C:42]2[C:37](=[CH:38][C:39](B3OC(C)(C)C(C)(C)O3)=[CH:40][N:41]=2)[CH:36]=[CH:35]1>>[CH3:19][S:20]([NH:23][CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[C:29]([C:9]2[S:10][C:5]3[C:4]([N:13]4[CH2:18][CH2:17][O:16][CH2:15][CH2:14]4)=[N:3][C:2]([C:39]4[CH:38]=[C:37]5[CH:36]=[CH:35][NH:34][C:42]5=[N:41][CH:40]=4)=[N:7][C:6]=3[C:8]=2[CH3:12])[CH:30]=1)(=[O:22])=[O:21]