HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-{[(Methanesulfonyl)amino]methyl}phenyl)boronic acid → n-Methylsulfonyl(3-(7-methyl-4-morpholino-2-(1h-pyrrolo[2,3-b]pyridin-5-yl)thieno[3,2-d]pyrimidin-6-yl)phenyl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-{[(Methanesulfonyl)amino]methyl}phenyl)boronic acid | HCID 22309453 | — |
| Reactant | 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo(2,3-b)pyridine | HCID 24208789 | — |
| Reactant | 2-Chloro-6-iodo-7-methyl-4-morpholinothieno[3,2-d]pyrimidine | HCID 59592880 | — |
| Product | n-Methylsulfonyl(3-(7-methyl-4-morpholino-2-(1h-pyrrolo[2,3-b]pyridin-5-yl)thieno[3,2-d]pyrimidin-6-yl)phenyl)methanamine | HCID 59592861 | — |
Reaction Steps
2-Chloro-6-iodo-7-methyl-4-morpholinothieno[3,2-d]pyrimidine (50 mg) was coupled to 3-methanesulphonylamino methyl benzeneboronic acid, and then reacted with 7-azaindole-5-boronic acid pinacol ester via General Procedure F. The product was purified by reverse phase HPLC to yield 34.5 mg of 424. MS (Q1) 535.2 (M)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07846929B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-cf41e71b66264160990200fa715a20db |
| Source note | uspto-grants-2010_12 |