反应详情

温度

25 °C

250 ml toluene were cooled to 0° C. and 40 g (0.4 mol) of phosgene were added. After warming up to 25° C., 13.8 g (0.1 mol) of 3-amino-2-cyano-4-ethyl-2-hexene in toluene were added. The reaction mixture was heated at 70° C. for 4 h, then the unreacted phosgene was removed by blowing out with dry N2. After cooling to 25° C. the product precipitated. Filtration and washing with diethyl ether gave 12 g (60% of theory) of the title compound as a yellow solid (m. p. 102° C.).

1. temperatureThe reaction mixture was heated at 70° C. for 4 h
2. customthe unreacted phosgene was removed
3. temperatureAfter cooling to 25° C. the product
4. customprecipitated
5. filtrationFiltration
6. washwashing with diethyl ether