HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2262447Generated: November 1, 2026
Phosgene → (2Z)-3-Amino-2-cyano-4-ethyl-2-hexenoyl chloride
https://huagongshe.com/reaction/2262447
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 3-Amino-4-ethyl-2-methylhex-2-enenitrile | HCID 57358235 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (2Z)-3-Amino-2-cyano-4-ethyl-2-hexenoyl chloride | HCID 86595835 | — |
Reaction Steps
250 ml toluene were cooled to 0° C. and 40 g (0.4 mol) of phosgene were added. After warming up to 25° C., 13.8 g (0.1 mol) of 3-amino-2-cyano-4-ethyl-2-hexene in toluene were added. The reaction mixture was heated at 70° C. for 4 h, then the unreacted phosgene was removed by blowing out with dry N2. After cooling to 25° C. the product precipitated. Filtration and washing with diethyl ether gave 12 g (60% of theory) of the title compound as a yellow solid (m. p. 102° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07851411B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-26d3f2a9d7d74954bc3dda81b1fafb7c |
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| Source note | uspto-grants-2010_12 |
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