Aluminium lithium hydride → (2R)-1,4-Dimethyl-2-piperazinemethanol

Participants

Reaction Conditions

Reaction Steps

(R)-2-hydroxymethyl-piperazine-1,4-dicarboxylic acid di-tert-butyl ester (6.24 g, 19.7 mmol) was dissolved in THF (10 mL) and cooled to 0° C. 2M LiAlH4 in THF (30.0 mL, 60.0 mmol) was added. The reaction mixture was stirred at reflux for 4 hours and then cooled to 0° C. and quenched with the drop-wise addition of 1M sodium hydroxide solution (20 mL). The reaction mixture was diluted with THF (50 mL), filtered and the filtrate was concentrated in vacuo to give 1,4-dimethyl-(R)-2-hydroxymethyl piperazine (1.77 g, 62%) as a colourless oil which was used without further purification.

Provenance & Evidence