反应详情

温度

0 °C

(R)-2-hydroxymethyl-piperazine-1,4-dicarboxylic acid di-tert-butyl ester (6.24 g, 19.7 mmol) was dissolved in THF (10 mL) and cooled to 0° C. 2M LiAlH4 in THF (30.0 mL, 60.0 mmol) was added. The reaction mixture was stirred at reflux for 4 hours and then cooled to 0° C. and quenched with the drop-wise addition of 1M sodium hydroxide solution (20 mL). The reaction mixture was diluted with THF (50 mL), filtered and the filtrate was concentrated in vacuo to give 1,4-dimethyl-(R)-2-hydroxymethyl piperazine (1.77 g, 62%) as a colourless oil which was used without further purification.

1. temperatureat reflux for 4 hours
2. temperaturecooled to 0° C.
3. customquenched with the drop-wise addition of 1M sodium hydroxide solution (20 mL)
4. additionThe reaction mixture was diluted with THF (50 mL)
5. filtrationfiltered
6. concentrationthe filtrate was concentrated in vacuo