Cyclopropylamine → HCID 25131101, compound

HRID 2262539Notes

Reaction equation

C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[C:13]([C:15]3[C:16]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[N:17][O:18][C:19]=3[C:20]([F:23])([F:22])[F:21])[N:12]=[CH:11]2)=[CH:6][CH:5]=1.[CH:31]1([NH2:34])[CH2:33][CH2:32]1>>[CH:31]1([NH:34][C:3](=[O:2])[C:4]2[CH:5]=[CH:6][C:7]([N:10]3[CH:14]=[C:13]([C:15]4[C:16]([C:24]5[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=5)=[N:17][O:18][C:19]=4[C:20]([F:21])([F:23])[F:22])[N:12]=[CH:11]3)=[CH:8][CH:9]=2)[CH2:33][CH2:32]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 25130783HCID 25130783, compound

Product 1

HCID 25131101HCID 25131101, compoundYield 27%

Procedure

As described for Example 10, 4-[4-(3-phenyl-5-trifluoromethyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid methyl ester (70 mg, 0.17 mmol) was converted, using cyclopropylamine instead of cyclopropanemethylamine, to the title compound (20 mg, 27%) which was obtained as a white solid. MS: m/e=439.2 [M+H]+.

Sources & evidence

ORD record: ord-d5088a3122524394a9051bc17a61660c
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07851469B2

Reaction notes

Loading…