4-Aminotetrahydropyran → HCID 25131102, compound

HRID 2262540Notes

Reaction equation

CO[C:3](=[O:30])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[C:13]([C:15]3[C:16]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[N:17][O:18][C:19]=3[C:20]([F:23])([F:22])[F:21])[N:12]=[CH:11]2)=[CH:6][CH:5]=1.[NH2:31][CH:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[C:24]1([C:16]2[C:15]([C:13]3[N:12]=[CH:11][N:10]([C:7]4[CH:8]=[CH:9][C:4]([C:3]([NH:31][CH:32]5[CH2:37][CH2:36][O:35][CH2:34][CH2:33]5)=[O:30])=[CH:5][CH:6]=4)[CH:14]=3)=[C:19]([C:20]([F:21])([F:22])[F:23])[O:18][N:17]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

Reactant 2

HCID 4192234-Aminotetrahydropyran

HCID 25130783HCID 25130783, compound

Product 1

HCID 25131102HCID 25131102, compoundYield 80%

Procedure

As described for Example 10, 4-[4-(3-phenyl-5-trifluoromethyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid methyl ester (80 mg, 0.19 mmol) was converted, using 4-aminotetrahydropyran instead of cyclopropanemethylamine, to the title compound (75 mg, 80%) which was obtained as a white foam. MS: m/e=483.2 [M+H]+.

Sources & evidence

ORD record: ord-0415162778df480fb9c6c22de8b1cf7c
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07851469B2

Reaction notes

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