Methyl 6-chloropyridine-3-carboxylate → HCID 25132124, compound

HRID 2262544Notes

Reaction equation

HRID 2262544 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[N:8][O:9][C:10]=2[C:11]([F:14])([F:13])[F:12])[N:3]=[CH:2]1.Cl[C:22]1[CH:31]=[CH:30][C:25]([C:26]([O:28][CH3:29])=[O:27])=[CH:24][N:23]=1>>[CH3:29][O:28][C:26](=[O:27])[C:25]1[CH:30]=[CH:31][C:22]([N:1]2[CH:5]=[C:4]([C:6]3[C:7]([C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=4)=[N:8][O:9][C:10]=3[C:11]([F:14])([F:12])[F:13])[N:3]=[CH:2]2)=[N:23][CH:24]=1

Participants

3

Reactant 2

HCID 254249Methyl 6-chloropyridine-3-carboxylateHCID 178506308HCID 178506308, compound

Product 1

HCID 25132124HCID 25132124, compoundYield 76%

Procedure

As described for Example 4, 4-(1H-imidazol-4-yl)-3-phenyl-5-trifluoromethyl-isoxazole (450 mg, 0.1.6 mmol) was converted, using methyl 6-chloronicotinate instead of 4-fluorobenzotrifluoride, to the title compound (510 mg, 76%) which was obtained as a white solid. MS: m/e=415.2 [M+H]+.

Sources & evidence

ORD record
ord-4610ecee8d7a41f8b7ecf8f939ec499f
Source dataset
uspto-grants-2010_12
Patent number
US07851469B2

Reaction notes

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