HCID 25130783, compound → HCID 25132478, compound

HRID 2262545Notes

Reaction equation

HRID 2262545 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[C:13]([C:15]3[C:16]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[N:17][O:18][C:19]=3[C:20]([F:23])([F:22])[F:21])[N:12]=[CH:11]2)=[N:6][CH:5]=1.COC(=O)C1C=CC(N2C=C(C3[C:46]([C:54]4[CH:59]=[CH:58]C=CC=4)=[N:47]OC=3C(F)(F)F)N=C2)=CC=1>>[CH:54]1([CH2:46][NH:47][C:3](=[O:2])[C:4]2[CH:9]=[CH:8][C:7]([N:10]3[CH:14]=[C:13]([C:15]4[C:16]([C:24]5[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=5)=[N:17][O:18][C:19]=4[C:20]([F:23])([F:22])[F:21])[N:12]=[CH:11]3)=[N:6][CH:5]=2)[CH2:59][CH2:58]1

Participants

3

Reactant 2

HCID 25130783HCID 25130783, compoundHCID 25132124HCID 25132124, compound

Product 1

HCID 25132478HCID 25132478, compoundYield 51%

Procedure

As described for Example 10, 6-[4-(3-phenyl-5-trifluoromethyl-isoxazol-4-yl)-imidazol-1-yl]-nicotinic acid methyl ester (90 mg, 0.22 mmol), instead of 4-[4-(3-phenyl-5-trifluoromethyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid methyl ester was converted, to the title compound (50 mg, 51%) which was obtained as a white solid. MS: m/e=454.2 [M+H]+.

Sources & evidence

ORD record
ord-370e2e4e46854e16b8b6358c68cb4d0c
Source dataset
uspto-grants-2010_12
Patent number
US07851469B2

Reaction notes

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