Morpholine → HCID 25132482, compound

HRID 2262549Notes

Reaction equation

HRID 2262549 reaction equation
CO[C:3](=[O:30])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[C:13]([C:15]3[C:16]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[N:17][O:18][C:19]=3[C:20]([F:23])([F:22])[F:21])[N:12]=[CH:11]2)=[N:6][CH:5]=1.[NH:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[N:31]1([C:3]([C:4]2[CH:5]=[N:6][C:7]([N:10]3[CH:14]=[C:13]([C:15]4[C:16]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)=[N:17][O:18][C:19]=4[C:20]([F:23])([F:21])[F:22])[N:12]=[CH:11]3)=[CH:8][CH:9]=2)=[O:30])[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 25132124HCID 25132124, compound

Product 1

HCID 25132482HCID 25132482, compoundYield 28%

Procedure

As described for Example 18, 6-[4-(3-phenyl-5-trifluoromethyl-isoxazol-4-yl)-imidazol-1-yl]-nicotinic acid methyl ester (90 mg, 0.22 mmol), was converted, using morpholine instead of cyclopropanemethylamine, to the title compound (28 mg, 28%) which was obtained as a yellow oil. MS: m/e=470.1 [M+H]+.

Sources & evidence

ORD record
ord-9666919570464c3b8f03528bd6cd8780
Source dataset
uspto-grants-2010_12
Patent number
US07851469B2

Reaction notes

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