3-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazole → 1-[3-(4-Chloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-ethanone

HRID 2262574노트

반응식

HRID 2262574 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[O:10][N:9]=2)=[CH:4][CH:3]=1.C1(C2[C:27](C3N=CN(C4C=CC=CC=4)C=3)=[C:26](C(F)(F)F)[O:25]N=2)C=CC=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([C:26](=[O:25])[CH3:27])=[C:11]([C:13]([F:14])([F:16])[F:15])[O:10][N:9]=2)=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 7993213-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazoleHCID 251304493-phenyl-4-(1-phenyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole

생성물 1

HCID 673624021-[3-(4-Chloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-ethanone수율 60%

실험 절차

As described for Example 1e, 3-(4-chloro-phenyl)-5-trifluoromethyl-isoxazole (36 g, 145.4 mmol), instead of 3-phenyl-4-(1-phenyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole, was converted to the title compound (25.2 g, 60%) which was obtained as a light orange oil. MS: m/e=287.9 [M−H]−.

출처 및 근거

ORD 기록
ord-18a96a83c73e4b4d87c06485adfd58c0
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851469B2

반응 노트

불러오는 중…