HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazole → 1-[3-(4-Chloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazole | HCID 799321 | — |
| Reactant | 3-phenyl-4-(1-phenyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole | HCID 25130449 | — |
| Product | 1-[3-(4-Chloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-ethanone | HCID 67362402 | 60% |
Reaction Steps
As described for Example 1e, 3-(4-chloro-phenyl)-5-trifluoromethyl-isoxazole (36 g, 145.4 mmol), instead of 3-phenyl-4-(1-phenyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole, was converted to the title compound (25.2 g, 60%) which was obtained as a light orange oil. MS: m/e=287.9 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851469B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-18a96a83c73e4b4d87c06485adfd58c0 |
| Source note | uspto-grants-2010_12 |