HCID 25130783, compound → HCID 25133158, compound

HRID 2262580Notes

Reaction equation

HRID 2262580 reaction equation
CO[C:3](=[O:31])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[C:13]([C:15]3[C:16]([C:24]4[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=4)=[N:17][O:18][C:19]=3[C:20]([F:23])([F:22])[F:21])[N:12]=[CH:11]2)=[N:6][CH:5]=1.COC(=O)C1C=CC(N2C=C(C3[C:47]([C:55]4[CH:60]=[CH:59]C=CC=4)=[N:48]OC=3C(F)(F)F)N=C2)=CC=1>>[Cl:30][C:27]1[CH:28]=[CH:29][C:24]([C:16]2[C:15]([C:13]3[N:12]=[CH:11][N:10]([C:7]4[CH:8]=[CH:9][C:4]([C:3]([NH:48][CH2:47][CH:55]5[CH2:60][CH2:59]5)=[O:31])=[CH:5][N:6]=4)[CH:14]=3)=[C:19]([C:20]([F:21])([F:23])[F:22])[O:18][N:17]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 25130783HCID 25130783, compoundHCID 67361949HCID 67361949, compound

Product 1

HCID 25133158HCID 25133158, compoundYield 83%

Procedure

As described for Example 10, 6-{4-[3-(4-chloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-imidazol-1-yl}-nicotinic acid methyl ester (100 mg, 0.23 mmol), instead of 4-[4-(3-phenyl-5-trifluoromethyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid methyl ester was converted, to the title compound (90 mg, 83%) which was obtained as a white solid. MS: m/e=488.1 [M+H]+.

Sources & evidence

ORD record
ord-ce37ebadc8ca4e06a0d598f7b3464351
Source dataset
uspto-grants-2010_12
Patent number
US07851469B2

Reaction notes

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