Ammonium Hydroxide → HCID 68686109, compound

HRID 2262660Notes

Reaction equation

HRID 2262660 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1[CH:11]=[C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)[CH:9]=[CH:8][C:7]=1[N+:19]([O-:21])=[O:20])C.[NH4+:23].[OH-]>>[CH3:18][N:15]1[CH2:16][CH2:17][N:12]([C:10]2[CH:9]=[CH:8][C:7]([N+:19]([O-:21])=[O:20])=[C:6]([CH2:5][C:4]([NH2:23])=[O:3])[CH:11]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 68686602HCID 68686602, compound

Product 1

HCID 68686109HCID 68686109, compound

Procedure

[5-(4-Methyl-piperazin-1-yl)-2-nitro-phenyl]-acetic acid ethyl ester (1.54 g, 5.01 mmol) is suspended in a 33% aqueous NH4OH solution (400 mL), and stirred for 3 days at RT. The volume is carefully reduced under vacuum until the title compound remains as a yellow solid, which is further dried under high vacuum. ES+-MS: 279 [M+H]+.

Sources & evidence

ORD record
ord-db31af3bb5b346ce9445fd8926f2e300
Source dataset
uspto-grants-2010_12
Patent number
US07851475B2

Reaction notes

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