HCID 68686602, compound → HCID 68689964, compound

HRID 2262667Notes

Reaction equation

HRID 2262667 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)[CH:9]=[CH:8][C:7]=1[N+:19]([O-])=O)[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[C:10]([N:12]2[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH2:17]2)[CH:9]=[CH:8][C:7]=1[NH2:19])[CH3:2]

Participants

4

Reactant 1

HCID 68686602HCID 68686602, compound

Product 1

HCID 68689964HCID 68689964, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of [5-(4-Methyl-piperazin-1-yl)-2-nitro-phenyl]-acetic acid ethyl ester (1.10 g, 3.58 mmol) in MeOH (25.0 mL) is added 10% Pd on charcoal (114 mg). The reaction mixture is stirred for 4 h under a hydrogen atmosphere (1 atm.), filtered through a microfilter (0.45 μM), and the filtrate concentrated at reduced pressure to afford the title compound as a red oil. ES+-MS: 278 [M+H]+.

Workup

  1. filtrationfiltered through a microfilter (0.45 μM)
  2. concentrationthe filtrate concentrated at reduced pressure

Sources & evidence

ORD record
ord-873efac38c3f421dbdc8b7692e25680f
Source dataset
uspto-grants-2010_12
Patent number
US07851475B2

Reaction notes

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