Ammonium Hydroxide → 2-Amino-5-chloro-3-fluoropyridine

Temperature

165 °C

To a stainless steel high pressure reactor was added 5-chloro-2,3-difluoropyridine (18.0 g) and ammonium hydroxide (65 mL). The reaction was heated to 165° C. for three hours. The reaction mixture was then cooled to room temperature and diluted with water (100 mL). The resultant solid was filtered, dried, re-dissolved in CH2Cl2, and passed through a silica gel plug to afford 12.8 g (73%) of the title compound as an off-white solid.

1. temperatureThe reaction mixture was then cooled to room temperature
2. filtrationThe resultant solid was filtered
3. customdried
4. dissolutionre-dissolved in CH2Cl2

ORD record

ord-7002adb02caf4e03b790037a49680e58

Source dataset

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07851484B2