Hydrochloric Acid → HCID 57513867, compound

HRID 2262720Notes

Reaction equation

HRID 2262720 reaction equation
[CH:1]1([N:5]2[CH2:10][CH2:9][N:8]([C:11](=[O:27])[CH2:12][N:13]3[CH2:18][CH2:17][CH:16]([NH:19]C(=O)OC(C)(C)C)[CH2:15][CH2:14]3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.Cl>C(Cl)Cl.O1CCOCC1>[CH:1]1([N:5]2[CH2:6][CH2:7][N:8]([C:11](=[O:27])[CH2:12][N:13]3[CH2:14][CH2:15][CH:16]([NH2:19])[CH2:17][CH2:18]3)[CH2:9][CH2:10]2)[CH2:2][CH2:3][CH2:4]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57442344HCID 57442344, compound

Product 1

HCID 57513867HCID 57513867, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of tert-butyl {1-[2-(4-cyclobutylpiperazin-1-yl)-2-oxoethyl]piperidin-4-yl}carbamate (9.2 mmol) in DCM, is added 4N HCl in dioxane (10 mL) slowly. The mixture is heated at 50° C. for 30 min. The solvent is removed in vacuo to give the title compound as a white solid (trihydrochloric acid salt).

Workup

  1. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-10fe5c2ac4b742ec9c81c882117c4591
Source dataset
uspto-grants-2010_12
Patent number
US07851474B2

Reaction notes

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