反应详情

温度

-78 °C

At −78° C., to liquid NH3 (20 ml) is added dropwise a solution of 1-benzylspiro[indole-3,4′-piperidin]-2(1H)-one (2 mmol) in THF (30 ml) and the mixture is stirred at −78° C. for 10 min. Li (42 mg, 6 mmol) is added in 3 portions and the resulting dark blue solution is stirred at −78° C. for 2 h. Anhydrous EtOH (1 ml) is added dropwise and the mixture is allowed to warm to rt overnight. Solvent is removed in vacuo and the resulting title compound (a light yellow solid) is used in the next step without further purification.

1. additionLi (42 mg, 6 mmol) is added in 3 portions
2. stirringthe resulting dark blue solution is stirred at −78° C. for 2 h
3. temperatureto warm to rt overnight
4. customSolvent is removed in vacuo
5. customthe resulting title compound (a light yellow solid) is used in the next step without further purification