Hydrochloric Acid → 4-(4-(2,5-Dimethylbenzyloxy)phenyl)-4-oxobutyric acid

HRID 2262785Notes

Reaction equation

HRID 2262785 reaction equation
[CH3:1][C:2]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:3]=1[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:20])[CH2:13][CH2:14][C:15]([O:17]CC)=[O:16])=[CH:8][CH:7]=1.[OH-].[Na+].Cl>C(O)C>[CH3:1][C:2]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([C:12](=[O:20])[CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21964479Ethyl 4-(4-(2,5-dimethylbenzyloxy)phenyl)4-oxobutyrate

Product 1

HCID 121323084-(4-(2,5-Dimethylbenzyloxy)phenyl)-4-oxobutyric acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of Ethyl 4-(4-(2,5-dimethylbenzyloxy)phenyl)-4-oxobutyrate (Step B, 2.62 g, 7.7 mmol) in abs ethanol (30 ml) was added 1N NaOH (10 ml) at room temperature. The reaction mixture was stirred for 3 hours and then acidified with 1M HCl. The occurring white precipitate was filtered, washed with water and dried under vacuum to provide the title compound as a white solid.

Workup

  1. filtrationThe occurring white precipitate was filtered
  2. washwashed with water
  3. customdried under vacuum

Sources & evidence

ORD record
ord-a0b5df9288674e6c99cd98771bbc528f
Source dataset
uspto-grants-2010_12
Patent number
US07851494B2

Reaction notes

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