反应详情

A solution of tert-butyl piperazine-1-carboxylate (1.21 g, 6.51 mmol) and 2-chloro-4-phenyl-1,3-oxazole (390 mg, 2.17 mmol) in xylene (50 ml) was stirred at 155° C. for 12 hours. The solvent was distilled off under reduced pressure. The residue was poured to water, and extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (hexane: ethyl acetate=9:1) to give 260 mg (12.1%) of the desired product as a solid.

1. distillationThe solvent was distilled off under reduced pressure
2. additionThe residue was poured to water
3. extractionextracted with ethyl acetate
4. washThe extract was washed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationThe solvent was distilled off under reduced pressure
7. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate=9:1)