Hydrochloric Acid → N-1,2-Benzisoxazol-3-yl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide hydrochloride

Participants

Reaction Steps

To a solution of N-1,2-benzisoxazol-3-yl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide (2.00 g, 4.92 mmol) in tetrahydrofuran (500 ml) was added a solution of 4 N hydrogen chloride in ethyl acetate (100 ml), and the mixture was stirred at room temperature for 5 hours and concentrated. Diethyl ether was added to the residue, and the desired product as a solid was separated by filtration.

Provenance & Evidence