Hydrochloric Acid → N-1,2-Benzisoxazol-3-yl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide hydrochloride

HRID 2263001Notes

Reaction equation

HRID 2263001 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([NH:10][C:11]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[S:23][N:22]=[C:21]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[N:20]=3)[CH2:15][CH2:14]2)=[O:12])=[N:2]1.[ClH:30]>O1CCCC1.C(OCC)(=O)C>[ClH:30].[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([NH:10][C:11]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[S:23][N:22]=[C:21]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[N:20]=3)[CH2:15][CH2:14]2)=[O:12])=[N:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11640074N-1,2-Benzisoxazol-3-yl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

Product 1

HCID 68777912N-1,2-Benzisoxazol-3-yl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide hydrochloride

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of N-1,2-benzisoxazol-3-yl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide (2.00 g, 4.92 mmol) in tetrahydrofuran (500 ml) was added a solution of 4 N hydrogen chloride in ethyl acetate (100 ml), and the mixture was stirred at room temperature for 5 hours and concentrated. Diethyl ether was added to the residue, and the desired product as a solid was separated by filtration.

Workup

  1. concentrationconcentrated
  2. additionDiethyl ether was added to the residue
  3. customthe desired product as a solid was separated by filtration

Sources & evidence

ORD record
ord-3ac68fdaa50749ddad7f1b2ca09fb1c3
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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