Tetrahydrofuran → HCID 45080306, compound

HRID 2263062Notes

Reaction equation

HRID 2263062 reaction equation
[NH2:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[N:6][C:7]=1Cl.[O:10]1CC[CH2:12][CH2:11]1.[OH-].[Na+]>[C].[Pd].C(O)C>[CH2:11]([O:10][C:3]1[C:2]([NH2:1])=[CH:7][N:6]=[CH:5][N:4]=1)[CH3:12]

Participants

6

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 794345-Amino-4,6-dichloropyrimidine

Product 1

HCID 45080306HCID 45080306, compoundYield 94.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A mixture of 5-amino-4,6-dichloropyrimidine (5.00 g, 30.5 mmol), tetrahydrofuran (100 ml), sodium hydroxide (2.44 g, 61.0 mmol), ethanol (100 ml) and 10% palladium-carbon (500 mg) was stirred under a hydrogen atmosphere at room temperature for 1 day, insolubles were filtered off and an organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to obtain the desired product (4.00 g, 94.3%) as an oil.

Workup

  1. filtrationinsolubles were filtered off
  2. customan organic layer was separated
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-4821ab020fe14197a041b5710bf0db72
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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