Hydrochloride methanol → 4-(4-Phenyl-1,3-thiazol-2-yl)piperidine dihydrochloride

HRID 2263124Notes

Reaction equation

HRID 2263124 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO.[ClH:27]>C(OCC)(=O)C>[ClH:27].[ClH:27].[C:1]1([C:7]2[N:8]=[C:9]([CH:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 67109295Tert-butyl 4-(4-phenyl-1,3-thiazol-2-yl)piperidine-1-carboxylate

Product 1

HCID 509882684-(4-Phenyl-1,3-thiazol-2-yl)piperidine dihydrochlorideYield 98.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-butyl 4-(4-phenyl-1,3-thiazol-2-yl)piperidine-1-carboxylate (1.35 g, 3.92 mmol), 2N hydrogen chloride methanol (100 ml) and ethyl acetate (10 ml) was stirred at room temperature for 12 hours and the solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solution of methanol and ether to obtain the desired product (1.08 g, 98.2%) as a solid.

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe residue was recrystallized from a mixed solution of methanol and ether

Sources & evidence

ORD record
ord-f3b439f6d9d24cc8bfa3715c8a20195b
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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