Hydrochloric Acid → HCID 68780263, compound

Participants

Reaction Steps

To a solution of 4-(4-phenyl-1,3-thiazol-2-yl)-N-pyridin-3-ylpiperazine-1-carboxamide (1.00 g, 2.74 mmol) in tetrahydrofuran (100 ml) was added a 4N solution of hydrogen chloride in ethyl acetate (20 ml) at room temperature. The mixture was stirred at room temperature for 2 hours and the solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solvent of diethyl ether and methanol to obtain the desired product (1.09 g, 99.0%) as a solid.

Provenance & Evidence