Hydrochloric Acid → HCID 68780263, compound

HRID 2263148Notes

Reaction equation

HRID 2263148 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([NH:20][C:21]4[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=4)=[O:19])[CH2:14][CH2:13]3)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:27]>O1CCCC1.C(OCC)(=O)C>[ClH:27].[C:1]1([C:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([NH:20][C:21]4[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=4)=[O:19])[CH2:14][CH2:13]3)[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11508866HCID 11508866, compound

Product 1

HCID 68780263HCID 68780263, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-(4-phenyl-1,3-thiazol-2-yl)-N-pyridin-3-ylpiperazine-1-carboxamide (1.00 g, 2.74 mmol) in tetrahydrofuran (100 ml) was added a 4N solution of hydrogen chloride in ethyl acetate (20 ml) at room temperature. The mixture was stirred at room temperature for 2 hours and the solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solvent of diethyl ether and methanol to obtain the desired product (1.09 g, 99.0%) as a solid.

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of diethyl ether and methanol

Sources & evidence

ORD record
ord-c0bb8d5c76ba4bdcb4dc901cc139da7a
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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