Imidazo(1,2-b)pyridazine, 6-chloro- → Imidazo[1,2-b]pyridazin-6-amine

HRID 2263155Notes

Reaction equation

HRID 2263155 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.O.[NH3:12]>>[N:10]1[CH:9]=[CH:8][N:6]2[C:5]=1[CH:4]=[CH:3][C:2]([NH2:12])=[N:7]2

Participants

3

Reactant 2

HCID 138828Imidazo(1,2-b)pyridazine, 6-chloro-HCID 12896473Azane;hydrate

Product 1

HCID 10534704Imidazo[1,2-b]pyridazin-6-amineYield 67.3%

Procedure

A solution of 6-chloroimidazo[1,2-b]pyridazine (5.00 g, 32.6 mmol) in a 25% aqueous ammonia water (50 ml) was stirred in a sealed tube at 180° C. for 8 hours, and the reaction solution was distilled off under reduced pressure. A form solid was separated by filtration, which was washed with water to give 2.94 g (67.3%) of the desired product as a solid.

Workup

  1. distillationthe reaction solution was distilled off under reduced pressure
  2. customA form solid was separated by filtration, which
  3. washwas washed with water

Sources & evidence

ORD record
ord-8583680fdfe74d53a30d4d3abbfa4a81
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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