Imidazo(1,2-b)pyridazine, 6-chloro- → Imidazo[1,2-b]pyridazin-6-amine

Participants

Reaction Steps

A solution of 6-chloroimidazo[1,2-b]pyridazine (5.00 g, 32.6 mmol) in a 25% aqueous ammonia water (50 ml) was stirred in a sealed tube at 180° C. for 8 hours, and the reaction solution was distilled off under reduced pressure. A form solid was separated by filtration, which was washed with water to give 2.94 g (67.3%) of the desired product as a solid.

Provenance & Evidence