Butyrophenone → 2-Bromo-1-phenylbutan-1-one

HRID 2263195Notes

Reaction equation

HRID 2263195 reaction equation
[C:1]1([C:7](=[O:11])[CH2:8][CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:12]Br>C(OCC)C>[Br:12][CH:8]([CH2:9][CH3:10])[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:11]

Participants

4

Reactant 2

HCID 10315ButyrophenoneHCID 24408Bromine

Product 1

HCID 526962-Bromo-1-phenylbutan-1-oneYield 72.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of 1-phenylbutan-1-one (10.0 g, 67.5 mmol) in diethyl ether (200 ml) was slowly added dropwise bromine (10.8 g, 67.5 mmol), and the mixture was stirred at room temperature for 4 hours. The reaction solution was distilled off under reduced pressure to give the desired product (11.1 g, 72.3%) as an oil.

Workup

  1. distillationThe reaction solution was distilled off under reduced pressure

Sources & evidence

ORD record
ord-a2e3b55f8b6a453fbae25d2af1e6283f
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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