Hydrochloric Acid → HCID 68778580, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[4-(3-fluorophenyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate (2.89 g, 7.95 mmol) in ethyl acetate (200 ml) was added a 4N solution (50 ml) of hydrogen chloride in ethyl acetate, and the mixture was stirred at room temperature for 30 hours. The solvent was distilled off under reduced pressure to give 1.86 g (70.0%) of the desired product as a solid.

Provenance & Evidence