Hydrochloric Acid → HCID 68778580, compound

HRID 2263208Notes

Reaction equation

HRID 2263208 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10](C3CCN(C(OC(C)(C)C)=O)CC3)[S:11][CH:12]=2)[CH:5]=[CH:6][CH:7]=1.[ClH:26].C(O[CH2:31][CH3:32])(=O)C>>[ClH:26].[ClH:26].[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([N:9]3[CH2:32][CH2:31][CH2:3][CH2:4][CH2:8]3)[S:11][CH:12]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl Acetate2×HCID 68780297HCID 68780297, compound

Product 1

HCID 68778580HCID 68778580, compoundYield 70%

Procedure

To a solution of tert-butyl 4-[4-(3-fluorophenyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate (2.89 g, 7.95 mmol) in ethyl acetate (200 ml) was added a 4N solution (50 ml) of hydrogen chloride in ethyl acetate, and the mixture was stirred at room temperature for 30 hours. The solvent was distilled off under reduced pressure to give 1.86 g (70.0%) of the desired product as a solid.

Workup

  1. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-4d24c02081d64f49bb0738723cf7e4b2
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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