Sodium Hydroxide → HCID 68777897, compound

HRID 2263213Notes

Reaction equation

HRID 2263213 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[S:12][CH:13]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>O>[F:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[S:12][CH:13]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68779420HCID 68779420, compound

Product 1

HCID 68777897HCID 68777897, compoundYield 3,291%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperidine hydrochloride (1.00 g, 2.99 mmol) was dissolved in water. The solution was neutralized with 1N aqueous sodium hydroxide solution, and the mixture was extracted with chloroform. The extract was washed with water and dried over magnesium sulfate anhydrous, and the solvent was distilled off under reduced pressure to give the desired product (772 mg, 98.4 mmol) as an oil.

Workup

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with water
  3. dry with materialdried over magnesium sulfate anhydrous
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-05d227207e3f4b9f9a2657aae5ef7c76
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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