反应详情

Propionyl chloride (25.0 g, 270 mmol) was added dropwise to a solution of 4-nitroaniline (24.9 g, 180 mmol) and pyridine (43.7 ml, 540 mmol) in tetrahydrofuran (500 ml) under ice-cooling, the mixture was stirred under ice-cooling for 2 hour, and the solvent was distilled off under reduced pressure. The residue was poured into ice-water, and 33.5 g (95.7%) of the desired product was collected by filtration as a solid.

1. temperaturecooling
2. temperaturecooling for 2 hour
3. distillationthe solvent was distilled off under reduced pressure
4. additionThe residue was poured into ice-water, and 33.5 g (95.7%) of the desired product
5. filtrationwas collected by filtration as a solid