3-Methoxyacetophenone → Bromomethyl 3-methoxyphenyl ketone

HRID 2263287Notes

Reaction equation

HRID 2263287 reaction equation
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:11](=[O:13])[CH3:12])[CH:8]=[CH:9][CH:10]=1>C(OCC)C>[Br:1][CH2:12][C:11]([C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([O:4][CH3:3])[CH:6]=1)=[O:13]

Participants

4

Reactant 2

HCID 114603-MethoxyacetophenoneHCID 24408Bromine

Product 1

HCID 101294Bromomethyl 3-methoxyphenyl ketone

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Bromine (5.32 g, 33.3 mmol) was slowly added dropwise to a solution of 1-(3-methoxyphenyl)ethanone (5.00 g, 33.3 mmol) in diethyl ether (100 ml), and the mixture was stirred at room temperature for 4 hours. The reaction mixture was distilled off under reduced pressure to give the desired product as an oil quantitatively.

Workup

  1. distillationThe reaction mixture was distilled off under reduced pressure

Sources & evidence

ORD record
ord-5b6139a469054981b4d25228d17d72d6
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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