Bromine → 2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one

HRID 2263295Notes

Reaction equation

HRID 2263295 reaction equation
[Br:1]Br.[F:3][C:4]([F:15])([F:14])[C:5]1[CH:6]=[C:7]([C:11](=[O:13])[CH3:12])[CH:8]=[CH:9][CH:10]=1>C(OCC)C>[Br:1][CH2:12][C:11]([C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([C:4]([F:14])([F:15])[F:3])[CH:6]=1)=[O:13]

Participants

4

Reactant 2

HCID 24408BromineHCID 676823'-(Trifluoromethyl)acetophenone

Product 1

HCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Bromine (4.25 g, 26.6 mmol) was slowly added dropwise to a solution of 1-[3-(trifluoromethyl)phenyl]ethanone (5.00 g, 26.6 mmol) in diethyl ether (100 ml), and the mixture was stirred at room temperature for 4 hours. The reaction mixture was distilled off under reduced pressure to give the desired product as an oil quantitatively.

Workup

  1. distillationThe reaction mixture was distilled off under reduced pressure

Sources & evidence

ORD record
ord-3aca497003b24d03ac8ecd0d7fdc15b4
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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