HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3'-(Trifluoromethyl)acetophenone | HCID 67682 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one | HCID 2778386 | — |
Reaction Steps
Bromine (4.25 g, 26.6 mmol) was slowly added dropwise to a solution of 1-[3-(trifluoromethyl)phenyl]ethanone (5.00 g, 26.6 mmol) in diethyl ether (100 ml), and the mixture was stirred at room temperature for 4 hours. The reaction mixture was distilled off under reduced pressure to give the desired product as an oil quantitatively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851473B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-3aca497003b24d03ac8ecd0d7fdc15b4 |
| Source note | uspto-grants-2010_12 |