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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2263295Generated: October 30, 2026

Bromine → 2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one

https://huagongshe.com/reaction/2263295

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBromineHCID 24408—
Reactant3'-(Trifluoromethyl)acetophenoneHCID 67682—
SolventDiethyl EtherHCID 3283—
Product2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-oneHCID 2778386—

Reaction Steps

Bromine (4.25 g, 26.6 mmol) was slowly added dropwise to a solution of 1-[3-(trifluoromethyl)phenyl]ethanone (5.00 g, 26.6 mmol) in diethyl ether (100 ml), and the mixture was stirred at room temperature for 4 hours. The reaction mixture was distilled off under reduced pressure to give the desired product as an oil quantitatively.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07851473B2
Source datasetuspto-grants-2010_12
ORD IDord-3aca497003b24d03ac8ecd0d7fdc15b4
Source noteuspto-grants-2010_12