Water → 2-Oxo-2-[3-(trifluoromethyl)phenyl]ethyl thiocyanate

HRID 2263296Notes

Reaction equation

HRID 2263296 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=[O:4].[S-:15][C:16]#[N:17].[K+].O>C(O)C>[O:4]=[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)[CH2:2][S:15][C:16]#[N:17]

Participants

5

Reactant 3

HCID 962WaterHCID 516872Potassium thiocyanateHCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one

Product 1

HCID 862452532-Oxo-2-[3-(trifluoromethyl)phenyl]ethyl thiocyanateYield 59.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (7.10 g, 26.6 mmol) and potassium thiocyanate (2.58 g, 26.6 mmol) in ethanol (70 ml) was stirred at 80° C. for 2 hours. After cooling to room temperature, water (70 ml) was poured to the reaction mixture, and crystals were collected by filtration, and washed with water to give 3.88 g (59.5%) of the desired product as a solid.

Workup

  1. filtrationwere collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-821561c3238e42f4b1b1a03869e5e1dd
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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