反应详情

To a solution of 5-chloro-3-phenyl-1,2,4-thiadiazole (196 mg, 1.00 mmol) and 1-(tert-butoxycarbonyl)-piperazine (186 mg, 1.00 mmol) in dimethylformamide (2 ml) was added triethylamine (0.558 ml, 4.00 mmol) at room temperature, and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured to water and extracted with ethyl acetate. The extract was washed with water, and the solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solvent of ethyl acetate and hexane to yield 181 mg (52.3%) of the desired product.

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water
3. distillationthe solvent was distilled off under reduced pressure
4. customThe residue was recrystallized from a mixed solvent of ethyl acetate and hexane