Sodium Chloride → HCID 12603684, compound

Participants

Reaction Steps

General Synthesis of 1-Dialkylamino-3-(3,5-dimethyl-pyrazol-1-yl)-propan-2-ols NaOH pellets (7.50 g, 0.188 mol) were added into a slightly heterogeneous mixture of 3,5-dimethylpyrazole (15.0 g, 0.156 mol) and epichlorohydrin (250 ml, 3.19 mol). After stirring for several minutes, NaCl began to precipitate and the reaction mixture was stirred at room temperature for 24 h. The resulting suspension was then filtered and the filtrate was evaporated under reduced pressure to give 3,5-dimethyl-1-oxiranylmethyl-1H-pyrazole as a viscous oil. This crude product, which contained 5-10% (by GC-MS) of 1,3-bis(3,5-dimethyl-1H-pyrazol-1-yl)propan-2-ol, was used in the preparation of the following compounds without purification.

Provenance & Evidence