Sodium Chloride → HCID 12603684, compound

HRID 2263448Notes

Reaction equation

HRID 2263448 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][N:3]=1.[CH2:8]([CH:10]1[O:12][CH2:11]1)Cl.[Na+].[Cl-]>>[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH2:8][CH:10]2[CH2:11][O:12]2)[N:3]=1

Participants

4

Reactant 3

HCID 5234Sodium ChlorideHCID 62103,5-DimethylpyrazoleHCID 7835Epichlorohydrin

Product 1

HCID 12603684HCID 12603684, compound

Procedure

General Synthesis of 1-Dialkylamino-3-(3,5-dimethyl-pyrazol-1-yl)-propan-2-ols NaOH pellets (7.50 g, 0.188 mol) were added into a slightly heterogeneous mixture of 3,5-dimethylpyrazole (15.0 g, 0.156 mol) and epichlorohydrin (250 ml, 3.19 mol). After stirring for several minutes, NaCl began to precipitate and the reaction mixture was stirred at room temperature for 24 h. The resulting suspension was then filtered and the filtrate was evaporated under reduced pressure to give 3,5-dimethyl-1-oxiranylmethyl-1H-pyrazole as a viscous oil. This crude product, which contained 5-10% (by GC-MS) of 1,3-bis(3,5-dimethyl-1H-pyrazol-1-yl)propan-2-ol, was used in the preparation of the following compounds without purification.

Workup

  1. customto precipitate
  2. stirringthe reaction mixture was stirred at room temperature for 24 h
  3. filtrationThe resulting suspension was then filtered
  4. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-706a84a48b1e40678426d1a592b854c2
Source dataset
uspto-grants-2010_12
Patent number
US07851570B2

Reaction notes

Loading…