Hydrochloric Acid → HCID 11529186, compound

Participants

Reaction Steps

Preparation according to Example 2: 1-ethyl-4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine (3.1 g, 11.3 mmol), palladium on carbon (0.3 g), hydrochloric acid (1.5 ml, conc), methanol (30 ml). Yield: 2.3 g (74%). The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 235-237° C. MS m/z (relative intensity, 70 eV) 275 (M+, 12), 261 (16), 260 (bp), 177 (10) 84 (13).

Provenance & Evidence