Hydrochloric Acid → HCID 11529186, compound

HRID 2263489Notes

Reaction equation

HRID 2263489 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[C:10]=2[F:19])[CH2:5][CH2:4]1)[CH3:2].Cl>[Pd].CO>[F:19][C:10]1[C:11]([C:15]([F:16])([F:17])[F:18])=[CH:12][CH:13]=[CH:14][C:9]=1[CH:6]1[CH2:7][CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][CH2:5]1

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 68776278HCID 68776278, compound

Product 1

HCID 11529186HCID 11529186, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Preparation according to Example 2: 1-ethyl-4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine (3.1 g, 11.3 mmol), palladium on carbon (0.3 g), hydrochloric acid (1.5 ml, conc), methanol (30 ml). Yield: 2.3 g (74%). The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 235-237° C. MS m/z (relative intensity, 70 eV) 275 (M+, 12), 261 (16), 260 (bp), 177 (10) 84 (13).

Workup

  1. customPreparation
  2. customrecrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-6069a6c237f14f18baea335a580e3284
Source dataset
uspto-grants-2010_12
Patent number
US07851629B2

Reaction notes

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