HCID 11557911, compound → HCID 57438790, compound

HRID 2263506Notes

Reaction equation

HRID 2263506 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1(O)[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH3:17])[CH2:11][CH2:10]1>FC(F)(F)C(O)=O>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH3:17])[CH2:11][CH:10]=1

Participants

3

Reactant 1

HCID 11557911HCID 11557911, compound

Product 1

HCID 57438790HCID 57438790, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Preparation according to preparation 4: 4-(2,3-difluorophenyl)-1-propylpiperidin-4-ol (6.43 g, 25.2 mmol), trifluoroacetic acid (40 ml). Yield: 3.35 g. MS m/z (rel. intensity, 70 eV) 237 (M+, 26), 209 (14), 208 (bp), 151 (20), 127 (23).

Workup

  1. customPreparation
  2. customaccording to preparation 4

Sources & evidence

ORD record
ord-fc615b1453704515a9a676a769641bff
Source dataset
uspto-grants-2010_12
Patent number
US07851629B2

Reaction notes

Loading…