Chloroacetaldehyde → 6-Bromoimidazo[1,2-a]pyrimidine

Temperature

25 °C

50 mmol of 5-bromo-pyrimidin-2-ylamine are dissolved in 200 ml of saturated aqueous sodium hydrogencarbonate solution. 55 mmol of chloroacetaldehyde are added to the reaction mixture and the mixture is stirred for 24 hours at 25° C. The mixture is extracted with ethyl acetate (3×300 ml) and the combined extracts are dried over sodium sulphate and evaporated under reduced pressure. Flash chromatography (SiO2 60 F) of the residue provides the title compound which is identified on the basis of its Rf-value.

1. extractionThe mixture is extracted with ethyl acetate (3×300 ml)
2. dry with materialthe combined extracts are dried over sodium sulphate
3. customevaporated under reduced pressure

ORD record

ord-4c8f846dd8ea46babfa0fd69beb84717

Source dataset

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07851634B2