HRID2263764

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22031678

1-Piperazinesulfonamide, N,N-dimethyl-, hydrochloride (1:1)

C6H16ClN3O2S

结构：CC(C)(C)OC(=O)N1CCC(N(C(=O)Nc2ncc(C=O)s2)C2CCCCC2)CC1

HCID86633694

未命名化合物

PRODUCTS

生成物

结构：CN(C)S(=O)(=O)N1CCN(Cc2cnc(NC(=O)N(C3CCCCC3)C3CCN(C(=O)OC(C)(C)C)CC3)s2)CC1

HCID57883705

未命名化合物

PROCEDURE

实验过程

Prepared in 55% (338 mg) yield as described in general procedure (B) from 4-[1-cyclohexyl-3-(5-formyl-thiazol-2-yl)ureido]-piperidine-1-carboxylic acid tert-butyl ester (436 mg, 1.0 mmol) and piperazine-1-sulfonic acid dimethylamide hydrochloride (230 mg, 1.0 mmol).

WORKUP

后处理

customPrepared in 55% (338 mg)
customyield

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e70e7eeae9ec486db6d65b5e78462a92
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07851636B2
来源说明: uspto-grants-2010_12

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[C:15]([NH:17][C:18]2[S:19][C:20]([CH:23]=O)=[CH:21][N:22]=2)=[O:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:32][N:33]([CH3:43])[S:34]([N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)(=[O:36])=[O:35]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[C:15]([NH:17][C:18]2[S:19][C:20]([CH2:23][N:40]3[CH2:41][CH2:42][N:37]([S:34](=[O:35])(=[O:36])[N:33]([CH3:32])[CH3:43])[CH2:38][CH2:39]3)=[CH:21][N:22]=2)=[O:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]