HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-dimethylpiperazine-1-sulfonamide hydrochloride → 4-{1-Cyclohexyl-3-[5-(4-dimethylsulfamoyl-piperazin-1-ylmethyl)-thiazol-2-yl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-dimethylpiperazine-1-sulfonamide hydrochloride | HCID 22031678 | — |
| Reactant | 4-[1-Cyclohexyl-3-(5-formyl-thiazol-2-yl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester | HCID 86633694 | — |
| Product | 4-{1-Cyclohexyl-3-[5-(4-dimethylsulfamoyl-piperazin-1-ylmethyl)-thiazol-2-yl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester | HCID 57883705 | — |
Reaction Steps
Prepared in 55% (338 mg) yield as described in general procedure (B) from 4-[1-cyclohexyl-3-(5-formyl-thiazol-2-yl)ureido]-piperidine-1-carboxylic acid tert-butyl ester (436 mg, 1.0 mmol) and piperazine-1-sulfonic acid dimethylamide hydrochloride (230 mg, 1.0 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851636B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-e70e7eeae9ec486db6d65b5e78462a92 |
| Source note | uspto-grants-2010_12 |