Isopropyl isocyanate → HCID 67071593, compound

Participants

Reaction Steps

To a solution of 4-piperidin-4-yl-piperazine-1-carboxylic acid tert-butyl ester (108 mg, 0.4 mmol, example 27) in dichloromethane (2 mL) was added isopropyl isocyanate. The mixture was stirred for 1 h and quenched with water. After aqueous workup with water and dichloromethane, the organic layers was dried over anhydrous magnesium sulfate. The solids were filtered off, and the filtrate was concentrated to give 4-(1-isopropylcarbamoyl-piperidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester as a viscous oil.

Provenance & Evidence