Isopropyl isocyanate → HCID 67071593, compound

HRID 2263911Notes

Reaction equation

HRID 2263911 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:20]([N:23]=[C:24]=[O:25])([CH3:22])[CH3:21]>ClCCl>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([CH:14]2[CH2:19][CH2:18][N:17]([C:24](=[O:25])[NH:23][CH:20]([CH3:22])[CH3:21])[CH2:16][CH2:15]2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 61277Isopropyl isocyanateHCID 17750356tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate

Product 1

HCID 67071593HCID 67071593, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-piperidin-4-yl-piperazine-1-carboxylic acid tert-butyl ester (108 mg, 0.4 mmol, example 27) in dichloromethane (2 mL) was added isopropyl isocyanate. The mixture was stirred for 1 h and quenched with water. After aqueous workup with water and dichloromethane, the organic layers was dried over anhydrous magnesium sulfate. The solids were filtered off, and the filtrate was concentrated to give 4-(1-isopropylcarbamoyl-piperidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester as a viscous oil.

Workup

  1. customquenched with water
  2. dry with materialAfter aqueous workup with water and dichloromethane, the organic layers was dried over anhydrous magnesium sulfate
  3. filtrationThe solids were filtered off
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-81cf1ed0b9bf4c0b958bb572c628eca5
Source dataset
uspto-grants-2010_12
Patent number
US07851626B2

Reaction notes

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