Trifluoroacetic acid → HCID 67071337, compound

HRID 2263912Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH:14]2[CH2:19][CH2:18][N:17]([C:20](=[O:25])[NH:21][CH:22]([CH3:24])[CH3:23])[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[CH:22]([NH:21][C:20]([N:17]1[CH2:18][CH2:19][CH:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH2:15][CH2:16]1)=[O:25])([CH3:24])[CH3:23]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67071593HCID 67071593, compound

Product 1

HCID 67071337HCID 67071337, compound

Procedure

In a manner analogous to the method described in example 27, 4-(1-isopropylcarbamoyl-piperidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester was treated with trifluoroacetic acid to give 4-piperazin-1-yl-piperidine-1-carboxylic acid isopropylamide trifluoroacetate as a yellow solid. LR-MS: 255 [(M+H)+]

Sources & evidence

ORD record: ord-147843b442d9422e9a120ce92605fb48
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07851626B2

Reaction notes

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